School of Mathematics and Natural Sciences

Professor Dr. Martin Simon

Molecular Cell Biology and Microbiology



Our reseach focuses on basic understanding of genetic and epigenetic mechanisms involving ribonucleic acid (RNA) as key regualtor in terms of gene-expression, development, epigentic inheritance and evolution.

In our work we aim to understand the various mechanisms in which small RNAs mediate epigentic information. Using molecular genetic methods in combination with NGS, we analyze sRNA, long RNA and chromatin modification on the genome wide level integrating data to understand cellular and systemic genome regulation and virus defence.


Two Piwis with Ago-like functions silence somatic genes at the chromatin level.
Drews F, Karunanithi S, Götz U, Marker S, deWijn R, Pirritano M, Rodrigues-Viana AM, Jung M, Gasparoni G, Schulz MH, Simon M
BioRxiv 2020.08.24.263970

Comparative analysis of biochemical biases by ligation- and templateswitch-based small RNA library peparation methods.
Meistertzheim M, Fehlmann T, Drews F, Pirritano M, Gasparoni G, Keller A, Simon M.
Clinical Chemistry, Volume 65, Issue 12, 1 December 2019, Pages 1581–1591

NGS analysis of total small non coding RNAs from low input RNA from dried blood sampling.
Pirritano M, Fehlmann T, Laufer T, Ludwig N, Gasparoni G, Li Y, Meese E, Keller A, Simon M.
Anal Chem. 2018 Oct 16;90(20):11791-11796.

Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis.
Dehghani Amirabad A, Ramasamy P, Wierz M, Nordström K, Kessler SM, Schulz MH, Simon M.
Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3099-3108.

Two sets of RNAi components are required for heterochromatin formation in trans by truncated transgenes.
Götz U, Marker S, Cheaib M, Andresen K, Shreshtha S, Durai D, Nordström K, Schulz MH, Simon M.
Nucleic Acids Research, Volume 44, Issue 12, 8 July 2016, Pages 5908–5923

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