School of Mathematics and Natural Sciences

Professor Dr. Guillaume Delaittre

Organic Functional Molecules



We synthesize macromolecules and nanostructures with applications in life sciences and are interested for the future in the development of biodegradable polymeric materials made from renewable resources.

Until now, our research activities have focused on the following main topics:

  • Self-assembled block copolymer nanostructured materials, in solid state or in solution, including polymerization-induced self-assembly
  • Protein stabilization using polymers, either via direct conjugation or by encapsulation in so-called single-enzyme nanogels (SENs)
  • Surface functionalization of different types of materials (glass/silicon, polymer) using efficient coupling methods such as click chemistry and mild photochemistry
  • Polymer synthesis and modification using most modern polymerization methods (nitroxide-mediated polymerization, RAFT polymerization, atom-transfer radical polymerization, cationic ring-opening polymerization, ring-opening metathesis polymerization) and modular coupling methods (click, photo)

In the near future, we want to include aspects of green chemistry, by harnessing mild and environmentally friendlier methodologies and renewable resources and by developing biodegradable polymeric materials.


Hetero-Diels–Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform
A. Beloqui, S. R. Mane, M. Langer, M. Glassner, D. M. Bauer, L. Fruk, C. Barner-Kowollik, G. Delaittre
Angew. Chem. Int. Ed. 2020, DOI: 10.1002/anie.202005747.

Straightforward Access to Biocompatible Poly(2-Oxazoline)-Coated Nanomaterials by Polymerization-Induced Self-Assembly
D. Le, F. Wagner, M. Takamiya, I.-L. Hsiao, G. Gil Alvaradejo, U. Straehle, C. Weiss, G. Delaittre
Chem. Commun. 2019, 55, 3741–3744.

Ultra-Fast Synthesis of Multivalent Radical Nanoparticles by Ring-Opening Metathesis Polymerization-Induced Self-Assembly
D. Le, M. Dilger, V. Pertici, S. Diabaté, D. Gigmes, C. Weiss, G. Delaittre
Angew. Chem. Int. Ed. 2019, 58, 4725–4731.

Surface-Reactive Patchy Nanoparticles and Nanodiscs Prepared by Tandem Nanoprecipitation and Internal Phase Separation
D. Varadharajan, H. Turgut, J. Lahann, H. Yabu, G. Delaittre
Adv. Funct. Mater. 2018, 28, 1800846.

A Simple Route to Highly Active Single-Enzyme Nanogels
A. Beloqui, A. Yu. Kobitski, G. U. Nienhaus, G. Delaittre
Chem. Sci. 2018, 9, 1006–1013.

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University of Wuppertal
Department of Mathematics and Natural Sciences
Gaußstraße 20
42119 Wuppertal

Room: V.10.069
Phone: +49-(0)-202-439-2535
Fax: +49-(0)-202-439-2648
E-Mail: delaittre{at}
Twitter: @GPRDelaittre
Web of Science: Profile

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